Beilstein J. Org. Chem.2015,11, 493–498, doi:10.3762/bjoc.11.55
required an HgO induced cyclization step, a mercury free variant is described herein.
Keywords: antisense; fluorescence correlation spectroscopy; guanidine; miRNA20a; peptide nucleic acids; Introduction
Sequence specific artificial ribonucleases are an attractive research target for several reasons. On
of fragments by gel electrophoresis in a DNA sequencer (Figure 1). Substrates 15 and 16 have been used for comparison with our previous studies [16]. The third substrate 17 has the sequence of miRNA20a, a member of the oncogenic miRNA 17–92 cluster [19] that is a promising target for site-specific
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Graphical Abstract
Scheme 1:
Formation of the 2-aminobenzimidazole moiety.